Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …

The advent of immunotherapy has marked a new era in cancer treatment, offering significant
clinical benefits. Cell membrane as drug delivery materials has played a crucial role in …

Primary sclerosing cholangitis is the classic hepatobiliary manifestation of inflammatory
bowel disease and is generally chronic and progressive. Patients frequently present with …

Cirrhosis is a multisystemic disease wherein inflammatory responses originating from
advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Rationale The liver-specific natural killer (NK) cell population is critical for local innate
immune responses, but the mechanisms that lead to their selective homing and the …

Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Innate immune system is the first line of defence against invading pathogens that is critical
for the overall survival of the host. Human liver is characterised by a dual blood supply, with …