The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer
amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although …

By using genome information to create tools for perturbing gene function, it is now possible
to undertake systematic genome-wide functional screens that examine the contribution of …

Many cancer-associated genes remain to be identified to clarify the underlying molecular
mechanisms of cancer susceptibility and progression. Better understanding is also required …

Early observations of centrosomes, made a century ago, revealed a tiny dark structure
surrounded by a radial array of cytoplasmic fibers. We now know that the fibers are …

Centrosomes act as sites of microtubule growth, but little is known about how the number
and stability of microtubules emanating from a centrosome are controlled during the cell …

Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main
microtubule (MT)-organizing centers in eukaryotic cells. Several proteins have been …

Microtubules (MTs) are dynamic polymers that undergo cell cycle and position-sensitive
regulation of polymerization and depolymerization. Although many different factors that …

▪ Abstract The one-cell Caenorhabditis elegans embryo divides asymmetrically into a larger
and smaller blastomere, each with a different fate. How does such asymmetry arise? The …

Cytokinesis ensures the proper partitioning of the nuclear and cytoplasmic contents into
independent daughter cells at the end of cell division. Although the metazoan mitotic spindle …

A major quest in cell biology is to understand the molecular mechanisms underlying the high
plasticity of the microtubule network at different stages of the cell cycle, and during and after …