Chlamydia cell biology and pathogenesis

C Elwell, K Mirrashidi, J Engel - Nature Reviews Microbiology, 2016 - nature.com
Chlamydia spp. are important causes of human disease for which no effective vaccine
exists. These obligate intracellular pathogens replicate in a specialized membrane …

[HTML][HTML] The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg

JN Bugalhão, LJ Mota - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly
causing ocular and urogenital infections that affect millions of people worldwide and which …

[HTML][HTML] Sequestration of host metabolism by an intracellular pathogen

L Gehre, O Gorgette, S Perrinet, MC Prevost… - Elife, 2016 - elifesciences.org
For intracellular pathogens, residence in a vacuole provides a shelter against cytosolic host
defense to the cost of limited access to nutrients. The human pathogen Chlamydia …

[HTML][HTML] Impact of Gentamicin Concentration and Exposure Time on Intracellular Yersinia pestis

TT VanCleave, AR Pulsifer, MG Connor… - Frontiers in Cellular …, 2017 - frontiersin.org
The study of intracellular bacterial pathogens in cell culture hinges on inhibiting extracellular
growth of the bacteria in cell culture media. Aminoglycosides, like gentamicin, were …

[HTML][HTML] The Pathogen-Occupied Vacuoles of Anaplasma phagocytophilum and Anaplasma marginale Interact with the Endoplasmic Reticulum

HK Truchan, CL Cockburn, KS Hebert… - Frontiers in cellular …, 2016 - frontiersin.org
The genus Anaplasma consists of tick-transmitted obligate intracellular bacteria that invade
white or red blood cells to cause debilitating and potentially fatal infections. A …

A chlamydial plasmid-dependent secretion system for the delivery of virulence factors to the host cytosol

L Lei, C Yang, MJ Patton, M Smelkinson, D Dorward… - MBio, 2021 - Am Soc Microbiol
Chlamydia are obligate intracellular Gram-negative bacteria distinguished by a unique
developmental biology confined within a parasitophorous vacuole termed an inclusion. The …

[HTML][HTML] Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs)

MA Recuero-Checa, M Sharma, C Lau, PA Watkins… - Scientific reports, 2016 - nature.com
The obligate-intracellular pathogen Chlamydia trachomatis (Ct) has undergone
considerable genome reduction with consequent dependence on host biosynthetic …

[HTML][HTML] Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions

V Lindenberg, K Mölleken, E Kravets, S Stallmann… - PloS one, 2017 - journals.plos.org
Chlamydia, the most common sexually transmitted pathogen, is an exquisitely adapted
Gram-negative obligate intracellular bacterium. Intracellular Chlamydia trachomatis replicate …

[HTML][HTML] Peptidase inhibitor 15 (PI15) regulates chlamydial CPAF activity

BK Prusty, SR Chowdhury, N Gulve… - Frontiers in cellular and …, 2018 - frontiersin.org
Obligate intracellular pathogenic Chlamydia trachomatis express several serine proteases
whose roles in chlamydial development and pathogenicity are not completely understood …

[HTML][HTML] Membrane contact sites between pathogen-containing compartments and host organelles

M Dumoux, RD Hayward - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Intracellular pathogens survive and replicate within specialised membrane-bound
compartments that can be considered as pseudo-organelles. Using the obligate intracellular …