Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …

Following their discovery in 1961, it was speculated that satellite cells were dormant
myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this …

Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem
cells (satellite cells), a process that becomes less efficient with aging. Here, we show that …

Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose
regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient …

Dystrophin is expressed in differentiated myofibers, in which it is required for sarcolemmal
integrity, and loss-of-function mutations in the gene that encodes it result in Duchenne …

A unique property of many adult stem cells is their ability to exist in a non-cycling, quiescent
state. Although quiescence serves an essential role in preserving stem cell function until the …

The niche is a conserved regulator of stem cell quiescence and function. During ageing,
stem cell function declines. To what extent and by what means age-related changes within …

A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal
muscle mass and strength,. Although the etiology of sarcopenia is unknown, the correlation …

The prospective isolation of purified stem cell populations has dramatically altered the field
of stem cell biology, and it has been a major focus of research across tissues in different …

Skeletal muscle tissue provides mechanical force for locomotion of all vertebrate animals. It
is prone to damage from acute physical trauma and physiological stress. To cope with this, it …