The role of lactoferrin in gastrointestinal and immune development and function: a preclinical perspective

SM Donovan - The Journal of pediatrics, 2016 - Elsevier
The early postnatal period is a critical time for gastrointestinal (GI) and immune
development. Neonates fed mother's milk have more rapid GI and immune development …

[HTML][HTML] Early-life nutrition and neurodevelopment: use of the piglet as a translational model

AT Mudd, RN Dilger - Advances in Nutrition, 2017 - Elsevier
Optimal nutrition early in life is critical to ensure proper structural and functional
development of infant organ systems. Although pediatric nutrition historically has …

Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig

AT Mudd, K Berding, M Wang, SM Donovan… - Gut …, 2017 - Taylor & Francis
ABSTRACT A dynamic relationship between the gut microbiota and brain is pivotal in
neonatal development. Dysbiosis of the microbiome may result in altered …

Dietary prebiotics, milk fat globule membrane, and lactoferrin affects structural neurodevelopment in the young piglet

AT Mudd, LS Alexander, K Berding… - Frontiers in …, 2016 - frontiersin.org
Introduction Milk fat globule membrane (MFGM) and lactoferrin have been identified as two
components that have potential to affect neurodevelopment. While concentrations of some …

[HTML][HTML] Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets

H Liu, EC Radlowski, MS Conrad, Y Li, RN Dilger… - The Journal of …, 2014 - Elsevier
Background: Because human breast milk is a rich source of phospholipids and gangliosides
and breastfed infants have improved learning compared with formula-fed infants, the …

[HTML][HTML] A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing

EA Koppes, BK Redel, MA Johnson, KJ Skvorak… - Jci Insight, 2020 - ncbi.nlm.nih.gov
Phenylalanine hydroxylase–deficient (PAH-deficient) phenylketonuria (PKU) results in
systemic hyperphenylalaninemia, leading to neurotoxicity with severe developmental …

Dietary sialyllactose influences sialic acid concentrations in the prefrontal cortex and magnetic resonance imaging measures in corpus callosum of young pigs

AT Mudd, SA Fleming, B Labhart, M Chichlowski… - Nutrients, 2017 - mdpi.com
Sialic acid (SA) is a key component of gangliosides and neural cell adhesion molecules
important during neurodevelopment. Human milk contains SA in the form of sialyllactose …

Delayed growth, motor function and learning in preterm pigs during early postnatal life

AD Andersen, PT Sangild, SL Munch… - American Journal …, 2016 - journals.physiology.org
Preterm birth interrupts normal fetal growth with consequences for postnatal growth and
organ development. In preterm infants, many physiological deficits adapt and disappear with …

Human and bovine milk oligosaccharides elicit improved recognition memory concurrent with alterations in regional brain volumes and hippocampal mRNA …

SA Fleming, AT Mudd, J Hauser, J Yan… - Frontiers in …, 2020 - frontiersin.org
Human milk contains a unique profile of oligosaccharides (OS) and preliminary evidence
suggests they impact brain development. The objective of this study was to assess the …

The domestic piglet: an important model for investigating the neurodevelopmental consequences of early life insults

MS Conrad, RW Johnson - Annu. Rev. Anim. Biosci., 2015 - annualreviews.org
Insults in the prenatal and early postnatal period increase the risk for behavioral problems
later in life. One hypothesis is that pre-and postnatal stressors influence structural and …