Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Pancreatic cancer (PC) remains a leading cause of mortality worldwide due to the absence
of early detection methods and the low success rates of traditional therapeutic strategies …

Purpose Pancreatic adenocarcinoma (PAAD) is one of the most common causes of death
among solid tumors, and its pathogenesis remains to be clarified. This study aims to …

Proteoglycans and selected extracellular matrix constituents are emerging as intrinsic and
critical regulators of evolutionarily conversed, intracellular catabolic pathways. Often, these …

Simple Summary Epidemiologic evidence and previous research have established obesity,
diabetes and the metabolic syndrome as risk factors for pancreatic cancer in humans, while …

Transcriptomic signatures based on cellular mRNA expression profiles can be used to
categorize cell types and states. Yet whether different functional groups of genes perform …

Gastrointestinal (GI) cancers, including colorectal cancer, pancreatic cancer, liver cancer
and gastric cancer, are severe social burdens due to high incidence and mortality rates …

Simple Summary Pancreatic cancer has a very low survival rate and improved treatments
are required. In addition to tumour cells, the disease is characterized by a significant non …

Purpose Chemotherapy is pivotal in the multimodal treatment of pancreatic ductal
adenocarcinoma (PDAC). Technical advances unveiled a high degree of inter-and …

The pancreas is a vital organ with digestive and endocrine roles, and diseases of the
pancreas affect millions of people yearly. A better understanding of the pancreas proteome …