The formyl peptide receptors: diversity of ligands and mechanism for recognition

HQ He, RD Ye - Molecules, 2017 - mdpi.com
The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce
chemotactic signals in phagocytes and mediate host-defense as well as inflammatory …

[HTML][HTML] The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation

DA Dorward, CD Lucas, GB Chapman, C Haslett… - The American journal of …, 2015 - Elsevier
Neutrophil migration to sites of inflammation and the subsequent execution of multiple
functions are designed to contain and kill invading pathogens. These highly regulated and …

Formyl peptide receptor 1 signaling potentiates inflammatory brain injury

Z Li, Y Li, J Han, Z Zhu, M Li, Q Liu, Y Wang… - Science translational …, 2021 - science.org
Acute brain insults elicit pronounced inflammation that amplifies brain damage in
intracerebral hemorrhage (ICH). We profiled perihematomal tissue from patients with ICH …

FPR2/ALXR agonists and the resolution of inflammation

O Corminboeuf, X Leroy - Journal of medicinal chemistry, 2015 - ACS Publications
The resolution of inflammation (RoI), once believed to be a passive process, has lately been
shown to be an active and delicately orchestrated process. During the resolution phase of …

[HTML][HTML] The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists

X Yi, E Tran, JO Odiba, CX Qin, RH Ritchie… - European journal of …, 2024 - Elsevier
Formyl peptide receptors (FPRs) comprise a class of chemoattractant pattern recognition
receptors, for which several physiological functions like host-defences, as well as the …

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

C Qin, YH Yang, L May, X Gao, AG Stewart, Y Tu… - Pharmacology & …, 2015 - Elsevier
Myocardial infarction (MI) and its resultant heart failure remains a major cause of death in
the world. The current treatments for patients with MI are revascularization with thrombolytic …

Chemotactic ligands that activate G-protein-coupled formylpeptide receptors

SA Krepel, JM Wang - International Journal of Molecular Sciences, 2019 - mdpi.com
Leukocyte infiltration is a hallmark of inflammatory responses. This process depends on the
bacterial and host tissue-derived chemotactic factors interacting with G-protein-coupled …

Flow cytometry: impact on early drug discovery

BS Edwards, LA Sklar - Journal of biomolecular screening, 2015 - journals.sagepub.com
Modern flow cytometers can make optical measurements of 10 or more parameters per cell
at tens of thousands of cells per second and more than five orders of magnitude dynamic …

Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition

IA Schepetkin, AI Khlebnikov… - Current medicinal …, 2014 - ingentaconnect.com
Formyl peptide receptors (FPRs) are G protein-coupled receptors (GPCRs) expressed on a
variety of cell types. These receptors play an important role in the regulation of inflammatory …

Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discovery

AV Oleinikov - Biochemistry (Moscow), 2022 - Springer
Specific adhesion (sequestration) of Plasmodium falciparum parasite-infected erythrocytes
(IEs) in deep vascular beds can cause severe complications resulting in death. This review …