The camera eye lens of vertebrates is a classic example of the re‐engineering of existing
protein components to fashion a new device. The bulk of the lens is formed from proteins …

Crystallins are the abundant, long-lived proteins of the eye lens. The major human
crystallins belong to two different superfamilies: the small heat-shock proteins (α-crystallins) …

γ-Crystallins constitute the major protein component in the nucleus of the vertebrate eye
lens. Present at very high concentrations, they exhibit extreme solubility and thermodynamic …

Proteins exposed to UV radiation are subject to irreversible photodamage through covalent
modification of tryptophans (Trps) and other UV-absorbing amino acids. Crystallins, the …

Aberrations in the methylation status of noncoding genomic repeat DNA sequences and
specific gene promoter region are important epigenetic events in melanoma progression …

The βγ-crystallin superfamily consists of evolutionarily related proteins with domain topology
similar to lens β-and γ-crystallins, formed from duplicated Greek key motifs. Ca2+ binding …

βγ-Crystallin-type double clamp (N/D)(N/D) XX (S/T) S motif is an established but sparsely
investigated motif for Ca 2+ binding. A βγ-crystallin domain is formed of two Greek key …

Background Genomic imprinting is an epigenetically regulated process wherein genes are
expressed in a parent-of-origin specific manner. Many imprinted genes were initially …

Abstract γ‐crystallins are highly specialized proteins of the vertebrate eye lens where they
survive without turnover under high molecular crowding while maintaining transparency …

Abstract βγ-Crystallins have emerged as a superfamily of structurally homologous proteins
with representatives across the domains of life. A major portion of this superfamily is …