Regular exercise offers protection against all-cause mortality, primarily by protection against
cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been …

It has recently been demonstrated that the marked increase in the systemic concentration of
cytokine interleukin‐6 (IL‐6) seen with exercise originates from the contracting limb and that …

Obesity alters adipose tissue metabolic and endocrine function and leads to an increased
release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity …

Most lifestyle-related chronic diseases are characterized by low-grade systemic
inflammation and insulin resistance. Excessive tumor necrosis factor-α (TNF-α) …

Background—Inflammation (assessed by C-reactive protein [CRP]) and the metabolic
syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based …

Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a
combination of genetic predisposition and environmental and lifestyle factors including lack …

The aim of the present study was to examine whether IL-6 and TNF-α are expressed in, and
released from, human skeletal muscle during exercise. We hypothesized that the skeletal …

Endothelial dysfunction comprises a number of functional alterations in the vascular
endothelium that are associated with diabetes and cardiovascular disease, including …

Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric
oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow …

OBJECTIVE—Recent evidence suggests that C-reactive protein (CRP) may predict
development of diabetes in Caucasian populations. We evaluated CRP as a possible risk …