Opioids are widely used as therapeutic agents against moderate to severe acute and
chronic pain. Still, these classes of analgesic drugs have many potential limitations as they …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Analysis of habituation is widely used to characterize animal cognitive phenotypes and their
modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral …

Positive allosteric modulators (PAMs) of the mu-opioid receptor (MOR) have been
hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on …

The NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3)
inflammasome is implicated in the pathogenesis of multiple diseases including …

Despite abundant evidence of sex differences in the effects of drugs on nonsexual
behaviour in rats and mice, most researchers continue to investigate male animals …

In the present study, we evaluated the stress response in adult rats who were administered
imidacloprid (IMI) orally in two doses (0.5 and 1.0 mg/kg bw for 60 days). It led to an …

The prevalence of opioid use disorder and overdose continues to harm the US population
and is further exacerbated by the use of the synthetic opioid, fentanyl, and its analogs …

Morphine is a potent analgesic opiate used to treat chronic pain, mostly in cancer patients. In
addition, it is widely used as a drug of abuse. Due to the continuous rise of morphine …

Background Estrogen deficiency is linked to changes in several physiological processes, but
the extent to which it associates with cognitive changes in menopause context is …