Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis
N Ilan, M Elkin, I Vlodavsky - The international journal of biochemistry & cell …, 2006 - Elsevier
Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …
Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases
S Rivara, FM Milazzo, G Giannini - Future medicinal chemistry, 2016 - Taylor & Francis
In recent years, heparanase has attracted considerable attention as a promising target for
innovative pharmacological applications. Heparanase is a multifaceted protein endowed …
innovative pharmacological applications. Heparanase is a multifaceted protein endowed …
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis
Purpose: Heparanase promotes myeloma growth, dissemination, and angiogenesis through
modulation of the tumor microenvironment, thus highlighting the potential of therapeutically …
modulation of the tumor microenvironment, thus highlighting the potential of therapeutically …
Glycomics approach to structure-function relationships of glycosaminoglycans
R Sasisekharan, R Raman… - Annu. Rev. Biomed …, 2006 - annualreviews.org
Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate
I Vlodavsky, N Ilan, A Naggi… - Current pharmaceutical …, 2007 - ingentaconnect.com
Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …
Glycosaminoglycans detection methods: Applications of mass spectrometry
F Kubaski, H Osago, RW Mason, S Yamaguchi… - Molecular genetics and …, 2017 - Elsevier
Glycosaminoglycans (GAGs) are long blocks of negatively charged polysaccharides. They
are one of the major components of the extracellular matrix and play multiple roles in …
are one of the major components of the extracellular matrix and play multiple roles in …
Re-visiting the structure of heparin
B Casu, A Naggi, G Torri - Carbohydrate research, 2015 - Elsevier
The sulfated polysaccharide heparin has been used as a life-saving anticoagulant in clinics
well before its detailed structure was known. This mini-review is a survey of the evolution in …
well before its detailed structure was known. This mini-review is a survey of the evolution in …
Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use
Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …
involved in various intertwined pathological processes including virus infection …
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting
Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate (HS) chains of
heparan sulfate proteoglycans on cell surfaces and in the extracellular matrix (ECM) …
heparan sulfate proteoglycans on cell surfaces and in the extracellular matrix (ECM) …
Heparanase: a target for drug discovery in cancer and inflammation
EA McKenzie - British journal of pharmacology, 2007 - Wiley Online Library
The remodelling of the extracellular matrix (ECM) has been shown to be highly upregulated
in cancer and inflammation and is critically linked to the processes of invasion and …
in cancer and inflammation and is critically linked to the processes of invasion and …