Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

In recent years, heparanase has attracted considerable attention as a promising target for
innovative pharmacological applications. Heparanase is a multifaceted protein endowed …

Purpose: Heparanase promotes myeloma growth, dissemination, and angiogenesis through
modulation of the tumor microenvironment, thus highlighting the potential of therapeutically …

Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …

Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

Glycosaminoglycans (GAGs) are long blocks of negatively charged polysaccharides. They
are one of the major components of the extracellular matrix and play multiple roles in …

The sulfated polysaccharide heparin has been used as a life-saving anticoagulant in clinics
well before its detailed structure was known. This mini-review is a survey of the evolution in …

Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …

Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate (HS) chains of
heparan sulfate proteoglycans on cell surfaces and in the extracellular matrix (ECM) …

The remodelling of the extracellular matrix (ECM) has been shown to be highly upregulated
in cancer and inflammation and is critically linked to the processes of invasion and …