Designing bioresponsive nanomaterials for intracellular self-assembly

S Chagri, DYW Ng, T Weil - Nature Reviews Chemistry, 2022 - nature.com
Supramolecular assemblies are essential components of living organisms. Cellular
scaffolds, such as the cytoskeleton or the cell membrane, are formed via secondary …

Fluorogenic probes for disease-relevant enzymes

J Zhang, X Chai, XP He, HJ Kim, J Yoon… - Chemical Society …, 2019 - pubs.rsc.org
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Enzymatic noncovalent synthesis

H He, W Tan, J Guo, M Yi, AN Shy, B Xu - Chemical reviews, 2020 - ACS Publications
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Synthesizing biomaterials in living organisms

X Zhang, J Wang, Y Zhang, Z Yang, J Gao… - Chemical Society …, 2023 - pubs.rsc.org
Living organisms fabricate biomacromolecules such as DNA, RNA, and proteins by the self-
assembly process. The research on the mechanism of biomacromolecule formation also …

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

D Ye, AJ Shuhendler, L Cui, L Tong, SS Tee… - Nature …, 2014 - nature.com
Directed self-assembly of small molecules in living systems could enable a myriad of
applications in biology and medicine, and already this has been used widely to synthesize …

Orderly Self‐Assembly of Organic Fluorophores for Sensing and Imaging

Z Li, PZ Liang, TB Ren, L Yuan… - Angewandte Chemie, 2023 - Wiley Online Library
Fluorescence imaging utilizing traditional organic fluorophores is extensively applied in both
cellular and in vivo studies. However, it faces significant obstacles, such as low signal‐to …

Facile syntheses of conjugated polymers for photothermal tumour therapy

P Chen, Y Ma, Z Zheng, C Wu, Y Wang… - Nature communications, 2019 - nature.com
Abstract Development of photothermal materials which are able to harness sunlight and
convert it to thermal energy seems attractive. Besides carbon-based nanomaterials …

Peptides as targeting elements and tissue penetration devices for nanoparticles

E Ruoslahti - Advanced materials, 2012 - Wiley Online Library
The use of nanoparticles in medicine (nanomedicine) has recently become an intensely
studied field. Nanoparticles carrying drugs and imaging agents have already reached the …

Advances in aggregatable nanoparticles for tumor-targeted drug delivery

W Yu, M Shevtsov, X Chen, H Gao - Chinese chemical letters, 2020 - Elsevier
Recent days, aggregatable nanoparticles, which can specifically respond to certain stimulus,
have shown great potential in tumor-targeted drug delivery with prolonged retention and …

Stimuli-Responsive Macrocyclization Scaffold Allows In Situ Self-Assembly of Radioactive Tracers for Positron Emission Tomography Imaging of Enzyme Activity

J Lin, D Gao, S Wang, G Lv, X Wang, C Lu… - Journal of the …, 2022 - ACS Publications
Target-enabled bioorthogonal reaction and self-assembly of a small-molecule probe into
supramolecules have shown promise for molecular imaging. In this paper, we report a new …