Nanomedicines for reactive oxygen species mediated approach: an emerging paradigm for cancer treatment

S Kwon, H Ko, DG You, K Kataoka… - Accounts of Chemical …, 2019 - ACS Publications
Conspectus Growth in the knowledge of cancer biology has led to the emergence and
evolution of cancer nanomedicines by providing the rationale for leveraging nanotechnology …

Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

VR Shinde, N Revi, S Murugappan, SP Singh… - Photodiagnosis and …, 2022 - Elsevier
Exploring the enhanced permeability and retention (EPR) effect through therapeutic
nanoparticles has been a subject of considerable interest in tumor biology. This passive …

An Ultrasound Activated Vesicle of Janus Au‐MnO Nanoparticles for Promoted Tumor Penetration and Sono‐Chemodynamic Therapy of Orthotopic Liver Cancer

X Lin, S Liu, X Zhang, R Zhu, S Chen… - Angewandte …, 2020 - Wiley Online Library
Sonodynamic therapy (SDT) has the advantages of high penetration, non‐invasiveness, and
controllability, and it is suitable for deep‐seated tumors. However, there is still a lack of …

Sustained release of nitric oxide and cascade generation of reactive nitrogen/oxygen species via an injectable hydrogel for tumor synergistic therapy

Y Wang, X Yang, X Chen, X Wang… - Advanced Functional …, 2022 - Wiley Online Library
Reactive nitrogen species (RNS) generated via the reaction of nitric oxide (NO) with reactive
oxygen species (ROS) are more lethal than ROS, and thus RNS‐mediated therapy has great …

Gas-mediated cancer bioimaging and therapy

L Chen, SF Zhou, L Su, J Song - ACS nano, 2019 - ACS Publications
Gas-involving cancer theranostics have attracted considerable attention in recent years due
to their high therapeutic efficacy and biosafety. We have reviewed the recent significant …

Nitric oxide‐driven nanomotor for deep tissue penetration and multidrug resistance reversal in cancer therapy

MM Wan, H Chen, Z Da Wang, ZY Liu, YQ Yu… - Advanced …, 2021 - Wiley Online Library
Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are
the two major challenges that lead to the failure of the current chemotherapy methods …

ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor

SS Wan, JY Zeng, H Cheng, XZ Zhang - Biomaterials, 2018 - Elsevier
This study reports a tumor-specific ROS-responsive nanoplatform capable of the
combination of nitric oxide (NO)-based gas therapy and sensitized photodynamic therapy …

Enhanced drug delivery by nanoscale integration of a nitric oxide donor to induce tumor collagen depletion

X Dong, HJ Liu, HY Feng, SC Yang, XL Liu, X Lai… - Nano …, 2019 - ACS Publications
Delivery of therapeutics into the solid tumor microenvironment is a major challenge for
cancer nanomedicine. Administration of certain exogenous enzymes which deplete tumor …

Graphene quantum dots-mediated theranostic penetrative delivery of drug and photolytics in deep tumors by targeted biomimetic nanosponges

SY Sung, YL Su, W Cheng, PF Hu, CS Chiang… - Nano …, 2018 - ACS Publications
Dual-targeted delivery of drugs and energy by nanohybrids can potentially alleviate side
effects and improve the unique features required for precision medicine. To realize this aim …

Recent progress in nitric oxide-generating nanomedicine for cancer therapy

Y Li, B Yoon, A Dey, JH Park - Journal of Controlled Release, 2022 - Elsevier
Nitric oxide (NO) is an endogenous, multipotent biological signaling molecule that
participates in several physiological processes. Recently, exogenous supplementation of …