Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Solute carrier (SLC) transporters meditate many essential physiological functions, including
nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and …

Background Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by
brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN) …

Current brain spheroids or organoids derived from human induced pluripotent stem cells
(hiPSCs) still lack a microglia component, the resident immune cells in the brain. The …

Astrocyte reactivation has been discovered to be an important contributor to several
neurological diseases. In vitro models involving human astrocytes have the potential to …

Importance Three-dimensional cerebral organoids generated from patient-derived induced
pluripotent stem cells (iPSCs) may be used to interrogate cellular-molecular underpinnings …

Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases,
interacting closely with other CNS cells but also with the immune system. However, due to …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Background Astrocytes play a central role in maintaining brain energy metabolism, but are
also tightly connected to the pathogenesis of Alzheimer's disease (AD). Our previous studies …

Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …