Auranofin (AF), a gold compound, has been used to treat rheumatoid arthritis (RA) for more
than 40 years; however, its mechanism of action remains unknown. We revealed that AF …

Chronic obstructive pulmonary disease (COPD) and lung cancer 17 are two of the most
prevalent and debilitating respiratory diseases worldwide, both associated with high …

There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin
reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has …

Vancomycin-resistant enterococci (VRE) are a serious public health threat and a leading
cause of healthcare-associated infections. Bacterial resistance to antibiotics recommended …

Vancomycin-resistant enterococci (VRE) represent a major public health threat that requires
the development of new therapeutics. In the present study, acetazolamide (AZM) was …

Gonococcal infections represent an urgent public health threat worldwide due to the
increasing incidence of infections that has been accompanied by an increase in bacterial …

Clostridioides difficile infections (CDIs) are responsible for a significant number of antibiotic-
associated diarrheal cases. The standard-of-care antibiotics for C. difficile are limited to …

Clostridioides difficile bacteria can cause life-threatening diarrhea and colitis owing to
limited treatment options and unacceptably high recurrence rates among infected patients …

Antimicrobial resistance has become a concern as a worldwide threat. A novel scaffold of
phenylthiazoles was recently evaluated against multidrug-resistant Staphylococci to control …

Clostridioides difficile causes a range of debilitating intestinal symptoms that may be fatal. It
is particularly problematic as a hospital-acquired infection, causing significant costs to the …