Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
AN Blackford, SP Jackson - Molecular cell, 2017 - cell.com
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
Non-homologous DNA end joining and alternative pathways to double-strand break repair
HHY Chang, NR Pannunzio, N Adachi… - … reviews Molecular cell …, 2017 - nature.com
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …
Nonhomologous DNA end-joining for repair of DNA double-strand breaks
NR Pannunzio, G Watanabe, MR Lieber - Journal of Biological Chemistry, 2018 - ASBMB
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …
DNA damage: from threat to treatment
A Carusillo, C Mussolino - Cells, 2020 - mdpi.com
DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
DNA damage kinase signaling: checkpoint and repair at 30 years
From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
DNA-PKcs: a multi-faceted player in DNA damage response
X Yue, C Bai, D Xie, T Ma, PK Zhou - Frontiers in genetics, 2020 - frontiersin.org
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
MR Lieber - Annual review of biochemistry, 2010 - annualreviews.org
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major
pathways for repairing them: homologous recombination (HR) and nonhomologous DNA …
pathways for repairing them: homologous recombination (HR) and nonhomologous DNA …
DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation
E Mladenov, S Magin, A Soni, G Iliakis - Seminars in cancer biology, 2016 - Elsevier
Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …
biochemical pathways that enable damage recognition and initiate responses leading to …
Repair of double-strand breaks by end joining
KK Chiruvella, Z Liang… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …