Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

Over the past 20 years we have seen a phenomenal increase in our understanding of the
diversity and the molecular mechanism of action of signal transduction systems. Now we are …

Extracellular nucleotides have been implicated in a number of physiological functions.
Nucleotides act on cell-surface receptors known as P2 receptors, of which several subtypes …

Arachidonic acid (AA) increased, at constant Ca2+, the levels of force and 20-kDa myosin
light chain (MLC20) phosphorylation in permeabilized smooth muscle, and slowed …

1. Vasodilatation induced by adenosine is mediated through the activation of A2‐
purinoceptors in endothelial and smooth muscle cells. 2. Adenosine induces a rapid and …

Nitric oxide (NO) is an important molecular messenger accounting for endothelium-derived
relaxing factor. Recently, NO synthase (NOS) from cultured endothelial cells has been …

1. Modulation of L‐arginine transport (system y+) and release of nitric oxide (NO) and
prostacyclin (PGI2) by elevated glucose and insulin were investigated in human cultured …

Cytoskeletal protein (CSP) interactions are critical to the contractile response in muscle and
non‐muscle cells. Current concepts suggest that activation of the contractile apparatus …

Abstract The secosteroid hormone 1, 25 (OH) 2-vitamin D 3 rapidly activates voltage-
dependent Ca 2+ channels of the l-type in skeletal and cardiac muscle cells by a non …

Exocytosis from Weibel-Palade bodies, the secretory granules of vascular endothelial cells,
causes the rapid release of von Willebrand factor (vWF), an adhesive glycoprotein involved …