Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

The blood–brain barrier (BBB) is an evolutionarily conserved, structural, and functional
separation between circulating blood and the central nervous system (CNS). By controlling …

Circadian rhythms oscillate throughout a 24-h period and impact many physiological
processes and aspects of daily life, including feeding behaviors, regulation of the sleep …

Advances in diagnostic technology, including chronic intracranial EEG recordings, have
confirmed the clinical observation of different temporal patterns of epileptic activity and …

Abstract Purpose of Review: The endogenous circadian rhythms are one of the cardinal
processes that control sleep. They are self-sustaining biological rhythms with a periodicity of …

Abstract Purpose of Review To review the mutual interactions between sleep and epilepsy,
including mechanisms of epileptogenesis, the relationship between sleep apnea and …

To design potentially more effective therapies, we need to further understand the
mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian …

Despite progress in the development of anti-seizure drugs, drug-resistant epilepsy (DRE)
occurs in a third of patients. DRE is associated with poor quality of life and increased risk of …

Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and
epilepsy. Comprehending how these interact with each other may help to advance our …

Background: Natural products are proved to play a good role as an alternative to synthetic
chemicals in many clinical conditions. Hypercholesterolemia is the most important risk factor …