Genetics, genomics, and diet interactions in obesity in the Latin American environment

P Guevara-Ramírez, S Cadena-Ullauri… - Frontiers in …, 2022 - frontiersin.org
Obesity is a chronic disease characterized by abnormal or excessive fat accumulation that
could impact an individual's health; moreover, the World Health Organization (WHO) has …

Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer

A López-Cortés, C Paz-y-Miño, S Guerrero… - The …, 2020 - nature.com
Colorectal cancer is one of the leading causes of cancer death worldwide. Over the last
decades, several studies have shown that tumor-related genomic alterations predict tumor …

Genetic ancestry and ethnic identity in Ecuador

SD Nagar, AB Conley, AT Chande, L Rishishwar… - Human Genetics and …, 2021 - cell.com
We investigated the ancestral origins of four Ecuadorian ethnic groups—Afro-Ecuadorian,
Mestizo, Montubio, and the Indigenous Tsáchila—in an effort to gain insight on the …

A comparative analysis of lung function and spirometry parameters in genotype-controlled natives living at low and high altitude

E Ortiz-Prado, S Encalada, J Mosquera… - BMC Pulmonary …, 2022 - Springer
Background The reference values for lung function are associated to anatomical and lung
morphology parameters, but anthropometry it is not the only influencing factor: altitude and …

The ancestry of eastern Paraguay: a typical south American profile with a unique pattern of admixture

F Simão, J Ribeiro, C Vullo, L Catelli, V Gomes… - Genes, 2021 - mdpi.com
Immigrants from diverse origins have arrived in Paraguay and produced important
demographic changes in a territory initially inhabited by indigenous Guarani. Few studies …

Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine

J Gallardo-Cóndor, P Naranjo… - … and Clinical Risk …, 2023 - Taylor & Francis
Purpose Thiopurine S-methyltransferase (TPMT) is an enzyme that metabolizes purine
analogs, agents used in the treatment of acute lymphoblastic leukemia. Improper drug …

Genetic diet interactions of ACE: the increased hypertension predisposition in the Latin American population

AK Zambrano, S Cadena-Ullauri… - Frontiers in …, 2023 - frontiersin.org
Hypertension is one of the primary risk factors associated with cardiovascular diseases
(CVDs). It is a condition that affects people worldwide, and its prevalence is increasing due …

Identifying genomic variant associated with long QT syndrome type 2 in an ecuadorian mestizo individual: a case report

R Tamayo-Trujillo, R Ibarra-Castillo… - Frontiers in …, 2024 - frontiersin.org
Introduction Long QT syndrome (LQTS) is an autosomal dominant inherited cardiac
condition characterized by a QT interval prolongation and risk of sudden death. There are 17 …

Investigating genetic diversity in admixed populations from Ecuador

R Flores‐Espinoza, E Paz‐Cruz… - American Journal of …, 2021 - Wiley Online Library
Objectives According to demographic history, Ecuador has experienced shifts in its Native
American populations caused by European colonization and the African slave trade. The …

[HTML][HTML] Feature selection reveal peripheral blood parameter's changes between COVID-19 infections patients from Brazil and Ecuador

BC Feltes, IA Vieira, J Parraga-Alava, J Meza… - Infection, Genetics and …, 2022 - Elsevier
The investigation of conventional complete blood-count (CBC) data for classifying the SARS-
CoV-2 infection status became a topic of interest, particularly as a complementary laboratory …