[HTML][HTML] Mechanisms of host manipulation by Neisseria gonorrhoeae

E Walker, S van Niekerk, K Hanning, W Kelton… - Frontiers in …, 2023 - frontiersin.org
Neisseria gonorrhoeae (also known as gonococcus) has been causing gonorrhoea in
humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an …

In vitro modelling of the physiological and diseased female reproductive system

A Stejskalova, H Vankelecom, M Sourouni, MY Ho… - Acta biomaterialia, 2021 - Elsevier
The maladies affecting the female reproductive tract (FRT) range from infections to
endometriosis to carcinomas. In vitro models of the FRT play an increasingly important role …

[HTML][HTML] Neisseria gonorrhoeae co-opts C4b-binding protein to enhance complement-independent survival from neutrophils

LM Werner, A Alcott, F Mohlin, JC Ray… - PLoS …, 2023 - journals.plos.org
Neisseria gonorrhoeae (Gc) is a human-specific pathogen that causes the sexually
transmitted infection gonorrhea. Gc survives in neutrophil-rich gonorrheal secretions, and …

Variable expression of opa proteins by Neisseria gonorrhoeae influences bacterial association and phagocytic killing by human neutrophils

AM Alcott, LM Werner, CM Baiocco… - Journal of …, 2022 - Am Soc Microbiol
Neisseria gonorrhoeae infection is characterized by local and abundant recruitment of
neutrophils. Despite neutrophils' antimicrobial activities, viable N. gonorrhoeae is recovered …

[PDF][PDF] Neisseria gonorrhoeae blocks epithelial exfoliation by nitric-oxide-mediated metabolic cross talk to promote colonization in mice

P Muenzner, CR Hauck - Cell host & microbe, 2020 - cell.com
Several pathogens suppress exfoliation, a key defense of epithelia against microbial
colonization. Common among these pathogens, exemplified by Neisseria gonorrhoeae, is …

[HTML][HTML] Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

S Gao, L Gao, D Yuan, X Lin, S van der Veen - Nature Communications, 2024 - nature.com
The bacterial pathogen Neisseria gonorrhoeae is able to invade epithelial cells and survive
intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however …

[HTML][HTML] Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea—challenges and opportunities

U Theuretzbacher, L Barbee, K Connolly… - Clinical Microbiology …, 2020 - Elsevier
Background Increasing multidrug resistance rates in Neisseria gonorrhoeae have raised
concerns and an urgent call for new antibiotics for treatment of gonorrhoea. Several …

[HTML][HTML] Intimate relations: molecular and immunologic interactions between Neisseria gonorrhoeae and HIV-1

F Guvenc, R Kaul, SD Gray-Owen - Frontiers in microbiology, 2020 - frontiersin.org
While the global incidence of human immunodeficiency virus (HIV-1) remains well above
UNAIDS targets, sexual transmission HIV is surprisingly inefficient. A variety of host, viral …

[HTML][HTML] Engagement of CEACAM1 by Helicobacter pylori HopQ Is Important for the Activation of Non-Canonical NF-κB in Gastric Epithelial Cells

K Taxauer, Y Hamway, A Ralser, A Dietl, K Mink… - Microorganisms, 2021 - mdpi.com
The gastric pathogen Helicobacter pylori infects half of the world's population and is a major
risk factor for gastric cancer development. In order to attach to human gastric epithelial cells …

[HTML][HTML] Tissue Models for Neisseria gonorrhoeae Research—From 2D to 3D

M Heydarian, E Rühl, R Rawal… - Frontiers in Cellular and …, 2022 - frontiersin.org
Neisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second
most common sexually transmitted infection worldwide. Disease progression, drug …