APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019 - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors

J Zhou, M Zaiss, L Knutsson, PZ Sun… - Magnetic resonance …, 2022 - Wiley Online Library
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …

Relaxation-compensated CEST-MRI of the human brain at 7 T: unbiased insight into NOE and amide signal changes in human glioblastoma

M Zaiss, J Windschuh, D Paech, JE Meissner, S Burth… - Neuroimage, 2015 - Elsevier
Endogenous chemical exchange saturation transfer (CEST) effects of protons resonating
near to water protons are always diluted by competing effects such as direct water saturation …

Predicting IDH mutation status in grade II gliomas using amide proton transfer‐weighted (APTw) MRI

S Jiang, T Zou, CG Eberhart… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To assess the amide proton transfer‐weighted (APTw) MRI features of isocitrate
dehydrogenase (IDH)‐wildtype and IDH‐mutant grade II gliomas and to test the hypothesis …

Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer …

HY Heo, Y Zhang, S Jiang, DH Lee… - Magnetic resonance in …, 2016 - Wiley Online Library
Purpose To evaluate the use of three extrapolated semisolid magnetization transfer
reference (EMR) methods to quantify amide proton transfer (APT) and nuclear Overhauser …

On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T

J Xu, M Zaiss, Z Zu, H Li, J Xie, DF Gochberg… - NMR in …, 2014 - Wiley Online Library
Chemical exchange saturation transfer (CEST) provides an indirect means to detect
exchangeable protons within tissues through their effects on the water signal. Previous …

Quantitative assessment of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) imaging with extrapolated semi‐solid magnetization transfer …

HY Heo, Y Zhang, DH Lee, X Hong… - Magnetic resonance in …, 2016 - Wiley Online Library
Purpose To quantify amide proton transfer (APT) and nuclear Overhauser enhancement
(NOE) contributions to in vivo chemical exchange saturation transfer MRI signals in tumors …

A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivo imaging

J Kim, Y Wu, Y Guo, H Zheng… - Contrast media & …, 2015 - Wiley Online Library
Chemical exchange saturation transfer (CEST) MRI is a versatile imaging method that
probes the chemical exchange between bulk water and exchangeable protons. CEST …

[HTML][HTML] Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas

S Jiang, CG Eberhart, Y Zhang, HY Heo, Z Wen… - European Journal of …, 2017 - Elsevier
Abstract Purpose Pathological assessment using World Health Organization (WHO) criteria
is the gold standard for diagnosis of gliomas. However, the accuracy of diagnosis is limited …

[HTML][HTML] A deep learning approach for magnetization transfer contrast MR fingerprinting and chemical exchange saturation transfer imaging

B Kim, M Schär, HW Park, HY Heo - Neuroimage, 2020 - Elsevier
Semisolid magnetization transfer contrast (MTC) and chemical exchange saturation transfer
(CEST) MRI based on MT phenomenon have shown potential to evaluate brain …