Moonlighting proteins at the candidal cell surface

D Satala, J Karkowska-Kuleta, A Zelazna… - Microorganisms, 2020 - mdpi.com
The cell wall in Candida albicans is not only a tight protective envelope but also a point of
contact with the human host that provides a dynamic response to the constantly changing …

Systems biology of fungal infection

F Horn, T Heinekamp, O Kniemeyer… - Frontiers in …, 2012 - frontiersin.org
Elucidation of pathogenicity mechanisms of the most important human-pathogenic fungi,
Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the …

Proteomics Unravels Extracellular Vesicles as Carriers of Classical Cytoplasmic Proteins in Candida albicans

A Gil-Bona, A Llama-Palacios, CM Parra… - Journal of proteome …, 2015 - ACS Publications
The commensal fungus Candida albicans secretes a considerable number of proteins and,
as in different fungal pathogens, extracellular vesicles (EVs) have also been observed. Our …

Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host–pathogen interaction

A Gil-Bona, CM Parra-Giraldo, ML Hernáez… - Journal of …, 2015 - Elsevier
The ability to switch from yeast to hyphal growth is essential for virulence in Candida
albicans. The cell surface is the initial point of contact between the fungus and the host. In …

Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile

CJ Heilmann, AG Sorgo, AR Siliakus… - …, 2011 - microbiologyresearch.org
The ability of Candida albicans to switch from yeast to hyphal growth is essential for its
virulence. The walls and especially the covalently attached wall proteins are involved in the …

Candida albicans hyphal extracellular vesicles are different from yeast ones, carrying an active proteasome complex and showing a different role in host immune …

R Martínez-López, ML Hernáez, E Redondo… - Microbiology …, 2022 - Am Soc Microbiol
Candida albicans is the principal causative agent of lethal fungal infections, predominantly
in immunocompromised hosts. Extracellular vesicles (EVs) have been described as crucial …

ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection

Y Zhou, M Liao, C Zhu, Y Hu, T Tong, X Peng… - International journal of …, 2018 - nature.com
The hyphal development of Candida albicans (C. albicans) has been considered as an
essential virulent factor for host cell damage. However, the missing link between hyphae …

Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent …

V Mascaraque, ML Hernaez… - Molecular & Cellular …, 2013 - ASBMB
The cell wall integrity (CWI) pathway of the model organism Saccharomyces cerevisiae has
been thoroughly studied as a paradigm of the mitogen-activated protein kinase (MAPK) …

Fungal proteomics: from identification to function

S Doyle - FEMS microbiology letters, 2011 - academic.oup.com
Some fungi cause disease in humans and plants, while others have demonstrable potential
for the control of insect pests. In addition, fungi are also a rich reservoir of therapeutic …

Mass Spectrometry-Based Proteomic and Immunoproteomic Analyses of the Candida albicans Hyphal Secretome Reveal Diagnostic Biomarker Candidates for …

C Vaz, A Pitarch, E Gómez-Molero, A Amador-García… - Journal of Fungi, 2021 - mdpi.com
Invasive candidiasis (IC) is associated with high morbidity and mortality in hospitalized
patients if not diagnosed early. Long-term use of central venous catheters is a predisposing …