The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

The immunostimulants 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and the saponin QS-
21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate …

Background A vaccine to interrupt the transmission of tuberculosis is needed. Methods We
conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E …

Chronic intestinal inflammation, as seen in inflammatory bowel disease (IBD), results from
an aberrant and poorly understood mucosal immune response to the microbiota of the …

Tuberculosis is the leading infectious disease killer globally due to a single pathogen.
Despite wide deployment of standard drug regimens, modern diagnostics and a vaccine …

Abstract Key Ags of Mycobacterium tuberculosis initially identified in the context of host
responses in healthy purified protein derivative-positive donors and infected C57BL/6 mice …

The tuberculosis (TB) pandemic continues to rampage despite widespread use of the BCG
(Bacillus Calmette–Guérin) vaccine. Novel vaccination strategies are urgently needed to …

Tuberculosis (TB), an ancient human scourge, is a growing health problem in the
developing world. Approximately two million deaths each year are caused by TB, which is …

The complete genome sequence of Corynebacterium glutamicum strain R was determined
to allow its comparative analysis with other corynebacteria. The biology of corynebacteria …

Abstract Background The Bacille Calmette–Guérin (BCG) tuberculosis (TB) vaccine provides
incomplete protection, necessitating development of an effective vaccine against TB …