The emerging role of extracellular vesicles in fungi: A double-edged sword

Y Lai, B Jiang, F Hou, X Huang, B Ling, H Lu… - Frontiers in …, 2023 - frontiersin.org
Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

Mechanisms of Alternaria pathogenesis in animals and plants

C Fernandes, A Casadevall… - FEMS Microbiology …, 2023 - academic.oup.com
Alternaria species are cosmopolitan fungi darkly pigmented by melanin that infect numerous
plant species causing economically important agricultural spoilage of various food crops …

A common vesicle proteome drives fungal biofilm development

R Zarnowski, H Sanchez, A Jaromin… - Proceedings of the …, 2022 - National Acad Sciences
Extracellular vesicles mediate community interactions among cells ranging from unicellular
microbes to complex vertebrates. Extracellular vesicles of the fungal pathogen Candida …

Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING

H Brown Harding, GN Kwaku, CM Reardon… - Nature …, 2024 - nature.com
The host type I interferon (IFN) pathway is a major signature of inflammation induced by the
human fungal pathogen, Candida albicans. However, the molecular mechanism for …

Extracellular vesicles regulate biofilm formation and yeast-to-hypha differentiation in Candida albicans

L Honorato, JFD de Araujo, CC Ellis, AC Piffer… - MBio, 2022 - Am Soc Microbiol
In this study, we investigated the influence of fungal extracellular vesicles (EVs) during
biofilm formation and morphogenesis in Candida albicans. Using crystal violet staining and …

Immunomodulatory potential of fungal extracellular vesicles: Insights for therapeutic applications

S Nenciarini, D Cavalieri - Biomolecules, 2023 - mdpi.com
Extracellular vesicles (EVs) are membranous vesicular organelles that perform a variety of
biological functions including cell communication across different biological kingdoms. EVs …

Extracellular Vesicles of the Plant Pathogen Botrytis cinerea

A De Vallée, JW Dupuy, C Moriscot, B Gallet… - Journal of Fungi, 2023 - mdpi.com
Fungal secretomes are known to contain a multitude of components involved in nutrition, cell
growth or biotic interactions. Recently, extra-cellular vesicles have been identified in a few …

Extracellular vesicles of Candida albicans regulate its own growth through the l-arginine/nitric oxide pathway

Y Wei, Z Wang, Y Liu, B Liao, Y Zong, Y Shi… - Applied Microbiology …, 2023 - Springer
Candida albicans is the main conditional pathogenic fungus among the human microbiome.
Extracellular vesicles (EVs) secreted by C. albicans are important for its pathogenesis …

Candida albicans Biofilm-Derived Extracellular Vesicles Are Involved in the Tolerance to Caspofungin, Biofilm Detachment, and Fungal Proteolytic Activity

J Karkowska-Kuleta, K Kulig, G Bras, K Stelmaszczyk… - Journal of Fungi, 2023 - mdpi.com
It has been repeatedly reported that the cells of organisms in all kingdoms of life produce
nanometer-sized lipid membrane-enveloped extracellular vesicles (EVs), transporting and …

Extracellular Vesicles from Candida haemulonii var. vulnera Modulate Macrophage Oxidative Burst

BTM Oliveira, TMH Dourado, PWS Santos… - Journal of Fungi, 2023 - mdpi.com
Members of the Candida haemulonii species complex are multidrug-resistant emergent
yeast pathogens able to cause superficial and invasive infections in risk populations. Fungal …