Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma
at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 …

The Aα, Bβ and γ polypeptide chains of fibrinogen are encoded by a three gene cluster on
human chromosome four. The fibrinogen genes (FGB-FGA-FGG) are expressed almost …

Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …

Cessation of bleeding after trauma is a necessary evolutionary vertebrate adaption for
survival. One of the major pathways regulating response to hemorrhage is the coagulation …

Many conserved noncoding sequences function as transcriptional enhancers that regulate
gene expression. Here, we report that protein-coding DNA also frequently contains …

Essentials• The fibrinogen gene cluster is flanked by CCCTC‐binding factor (CTCF)
interaction sites.• Chromatin looping of the fibrinogen cluster was demonstrated by …

The plasma protein fibrinogen is encoded by 3 structural genes (FGA, FGB, and FGG) that
are transcribed to mRNA, spliced, and translated to 3 polypeptide chains (Aα, Bβ, and γ …

Fibrinogen is an important plasma protein composed of three polypeptide chains, fibrinogen
alpha (FGA), beta, and gamma. Apart from being an inflammation regulator, fibrinogen also …

Since the early inception of genome‐wide association studies (GWAS), it became clear that,
in all diseases or traits studied, most genetic variants are likely to exert their effect on gene …

Population and family-based genetic studies typically result in the identification of genetic
variants that are statistically associated with a clinical disease or phenotype. For many …