The available data concerning the ability of ceramide and other simple sphingolipids to
segregate laterally into rigid, gel-like domains in a fluid bilayer has been reviewed …

Sphingolipids in general and ceramides in particular, contribute to pathophysiological
mechanisms by modifying signalling and metabolic pathways. Here, we present the …

Recognition of lipids by proteins is important for their targeting and activation in many
signaling pathways, but the mechanisms that regulate such interactions are largely …

Phosphatidic acid is the simplest (diacyl) glycerophospholipid present in cells and is now a
well established second messenger with direct biological functions. It is specifically …

Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated
forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial …

Phosphatidylinositol polyphosphate lipids (phosphoinositides) form only a minor pool of
membrane phospholipids but are involved in many intracellular signaling processes …

Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid
synthesis and numerous intracellular signaling cascades. The signaling function of PA is …

Some of the simplest sphingolipids, namely sphingosine, ceramide and their
phosphorylated compounds [sphingosine 1-phosphate (Sph-1-P) and ceramide 1 …

Sphingomyelins are important phospholipids in plasma membranes of most cells. Because
of their dominantly saturated nature, they affect the lateral structure of membranes, and …

Biological membranes are renowned for their intricate complexity, with the formation of
membrane domains being pivotal to the successful execution of numerous cellular …