Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …

Although traditionally considered a glucose metabolism-associated modification, the O-
linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids …

Background Peroxisome proliferator-activated receptor gamma (PPARγ) is an enhancer of
Treg responses, but the mechanisms remain elusive. This study aimed to solve this problem …

Asthma exacerbations caused by respiratory viral infections are a serious global health
problem. Impaired antiviral immunity is thought to contribute to the pathogenesis, but the …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …

The enzymatic modification of protein serine or threonine residues by N-acetylglucosamine,
namely O-GlcNAcylation, is a ubiquitous post-translational modification that frequently …

Compensation is a defining principle of a true circadian clock, where its approximately 24-
hour period length is relatively unchanged across environmental conditions. Known …

The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles
of environmental light. Fundamental mechanisms of how the circadian clock regulates organ …

Impaired brain glucose metabolism is considered a hallmark of brain dysfunction and
neurodegeneration. Disruption of the hexosamine biosynthetic pathway (HBP) and …

TIMELESS (TIM) was first identified as a molecular cog in the Drosophila circadian clock.
Almost three decades of investigations have resulted in an insightful model describing the …