The importance of microfluidics for the preparation of nanoparticles as advanced drug delivery systems

JP Martins, G Torrieri, HA Santos - Expert opinion on drug delivery, 2018 - Taylor & Francis
Introduction: Nanoparticles are anticipated to overcome persistent challenges in efficient
drug delivery, but the limitations associated with conventional methods of preparation are …

Theranostic design of angiopep-2 conjugated hyaluronic acid nanoparticles (Thera-ANG-cHANPs) for dual targeting and boosted imaging of glioma cells

A Costagliola di Polidoro, G Zambito, J Haeck… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma multiforme is the most aggressive malignant brain tumor with
poor patient prognosis. The presence of the blood-brain barrier and the complex tumor …

A microfluidic platform to design multimodal PEG-crosslinked hyaluronic acid nanoparticles (PEG-cHANPs) for diagnostic applications

O Tammaro, A Costagliola di Polidoro, E Romano… - Scientific reports, 2020 - nature.com
The combination of different imaging modalities can allow obtaining simultaneously
morphological and functional information providing a more accurate diagnosis. This …

On-chip control over polyelectrolyte–surfactant complexation in nonequilibrium microfluidic confinement

A Bezrukov, Y Galyametdinov - Polymers, 2022 - mdpi.com
The goal of this work is to classify and quantify the factors that govern polyelectrolyte–
surfactant complexation in microfluidic confinement and optimize the designs and operating …

Insulin Activation Mediated by Uptake Mechanisms: A Comparison of the Behavior between Polymer Nanoparticles and Extracellular Vesicles in 3D Liver Tissues

A Costagliola di Polidoro, Z Baghbantarghdari… - …, 2023 - ACS Publications
In this work, we compare the role of two different uptake mechanisms in the effectiveness of
a nanoformulated drug, specifically insulin. Insulin is activated by interacting with insulin …

Activation and switching of supramolecular chemical signals in multi-output microfluidic devices

A Bezrukov, Y Galyametdinov - Micromachines, 2022 - mdpi.com
In this study, we report on the developing of a continuous microfluidic reaction device that
allows selective activation of polyelectrolyte-surfactant chemical signals in microflows and …

Targeting nanostrategies for imaging of atherosclerosis

A Costagliola di Polidoro, A Grassia… - Contrast Media & …, 2021 - Wiley Online Library
Despite the progress in cardiovascular research, atherosclerosis still represents the main
cause of death worldwide. Clinically, the diagnosis of Atherosclerotic Cardiovascular …

[HTML][HTML] Water-mediated nanostructures for enhanced MRI: impact of water dynamics on relaxometric properties of Gd-DTPA

F De Sarno, AM Ponsiglione, M Russo, AM Grimaldi… - Theranostics, 2019 - ncbi.nlm.nih.gov
Recently, rational design of a new class of contrast agents (CAs), based on biopolymers
(hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) …

Glycosaminoglycans and contrast agents: The role of hyaluronic acid as MRI contrast enhancer

AM Ponsiglione, M Russo, E Torino - Biomolecules, 2020 - mdpi.com
A comprehensive understanding of the behaviour of Glycosaminoglycans (GAGs) combined
with imaging or therapeutic agents can be a key factor for the rational design of drug delivery …

HA PEGylated filler in association with an infrared energy device for the treatment of facial skin aging: 150 day follow-up data report

P Kubik, J Jankau, R Rauso, H Galadari, M Protasoni… - Pharmaceuticals, 2022 - mdpi.com
Background: The face is the area most exposed to the normal course of skin aging, both
intrinsically and extrinsically. The aim of the study was to evaluate the cellular and clinical …