The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage
disease, obesity and other related diseases. Intriguingly, recent studies have revealed that …

Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

The study of metabolism has provided remarkable information about the biological basis
and therapeutic weaknesses of cancer cells. Classic biochemistry established the …

Tumor development and progression depend on reprogramming of signaling pathways that
regulate cell metabolism. Alterations to various metabolic pathways such as glycolysis …

Liver fibrosis is a pathological result of liver injury that usually leads to a pathophysiological
wound healing response. The total alkaloids of Corydalis saxicola Bunting (TACS) have …

Abnormal lipid metabolism is a hallmark of tumorigenesis. Hence, the alterations of
metabolism enhance the development of hepatocellular carcinoma (HCC). Aspirin is able to …

Colorectal cancer (CRC) is one of the major public health and socio-economic problems,
which management demands the development of non-invasive screening tests. Assessment …

Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over
3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally …

Developing specific chemical functionalities to deploy in biological environments for
targeted enzyme inactivation lies at the heart of mechanism-based inhibitor development but …

Elevated polyamine levels are required for tumor transformation and development; however,
expression patterns of polyamines and their diagnostic potential have not been investigated …