This chapter describes algorithmic advances in the RELION software, and how these are
used in high-resolution cryo-electron microscopy (cryo-EM) structure determination. Since …

Dengue virus affects hundreds of millions of people each year around the world, causing a
tremendous social and economic impact on affected countries. The aim of this review is to …

Human γ-secretase is an intra-membrane protease that cleaves many different substrates.
Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid …

Tick‐borne encephalitis virus (TBEV) is a flavivirus commonly found in at least 27 European
and Asian countries. It is an emerging public health problem, with steadily increasing case …

Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea,
are responsible for considerable morbidity and mortality worldwide. Recent advances in our …

Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe
disease that can lead to permanent neurological complications or death and the incidence …

Flavivirus assembles into an inert particle that requires proteolytic activation by furin to
enable transmission to other hosts. We previously showed that immature virus undergoes a …

Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally
circulate between arthropod vectors and susceptible vertebrate hosts, producing significant …

Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled
insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double …

Dengue virus (DENV) is an emerging mosquito-borne human pathogen that affects millions
of individuals each year by causing severe and potentially fatal syndromes. Despite intense …