Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale

FE Liew, R Nogle, T Abdalla, BJ Rasor, C Canter… - Nature …, 2022 - nature.com
Many industrial chemicals that are produced from fossil resources could be manufactured
more sustainably through fermentation. Here we describe the development of a carbon …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Machine learning for metabolic engineering: A review

CE Lawson, JM Martí, T Radivojevic… - Metabolic …, 2021 - Elsevier
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …

[HTML][HTML] Energy and environmental assessment of hydrogen from biomass sources: Challenges and perspectives

M Buffi, M Prussi, N Scarlat - Biomass and Bioenergy, 2022 - Elsevier
Hydrogen is considered as one of the pillars of the European decarbonisation strategy,
boosting a novel concept of the energy system in line with the EU's commitment to achieve …

Scalability of microbial electrochemical technologies: Applications and challenges

DA Jadhav, SG Park, S Pandit, E Yang… - Bioresource …, 2022 - Elsevier
During wastewater treatment, microbial electrochemical technologies (METs) are a
promising means for in situ energy harvesting and resource recovery. The primary constraint …

Engineering robust production microbes for large-scale cultivation

M Wehrs, D Tanjore, T Eng, J Lievense, TR Pray… - Trends in …, 2019 - cell.com
Systems biology and synthetic biology are increasingly used to examine and modulate
complex biological systems. As such, many issues arising during scaling-up microbial …

[HTML][HTML] Dynamic control in metabolic engineering: Theories, tools, and applications

CJ Hartline, AC Schmitz, Y Han, F Zhang - Metabolic engineering, 2021 - Elsevier
Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

Natural bioactive products as promising therapeutics: A review of natural product-based drug development

CB Aware, DN Patil, SS Suryawanshi, PR Mali… - South African Journal of …, 2022 - Elsevier
Since ancient times, natural medicines have had paramount importance in bolstering
biotherapeutics to treat various diseases. The World Health Organization (WHO) revealed …