Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Cellular and non-cellular components of the tumor microenvironment (TME) are emerging
as key regulators of primary tumor progression, organ-specific metastasis, and therapeutic …

Immunotherapy based on immune checkpoint inhibitors has evolved into a new pillar of
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …