Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Highlights•Solid organ transplantation (SOT) patients or patients with active ADs have been
largely excluded from ICIs clinical trials because of the risk of allograft rejection or severe …

The aim was to update the 2009 European League against Rheumatism (EULAR)
recommendations for the treatment of systemic sclerosis (SSc), with attention to new …

Background Systemic sclerosis is a rare disabling autoimmune disease with few treatment
options. The efficacy and safety of tocilizumab, an interleukin 6 receptor-α inhibitor, was …

Objectives Assess the efficacy and safety of tocilizumab in patients with systemic sclerosis
(SSc) in a phase II study. Methods Patients with SSc were treated for 48 weeks in an open …

Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that
is characterised by fibrosis of the skin and internal organs and vasculopathy. Although …

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ
involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous …

The term 'sclerosing diseases of the skin'comprises specific dermatological entities, which
have fibrotic changes of the skin in common. These diseases mostly manifest in different …

Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three
different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse …