Matrix metalloproteinases shape the tumor microenvironment in cancer progression
S Niland, AX Riscanevo, JA Eble - International journal of molecular …, 2021 - mdpi.com
Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma
T Sasahira, T Kirita - International journal of molecular sciences, 2018 - mdpi.com
Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …
[PDF][PDF] Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: prediction and impact on long‐term survival
J Altamirano, H López‐Pelayo, J Michelena… - …, 2017 - Wiley Online Library
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease. Most studies have
focused on short‐term prognosis, whereas factors associated with long‐term survival are …
focused on short‐term prognosis, whereas factors associated with long‐term survival are …
Slow-cycling cancer stem cells regulate progression and chemoresistance in colon cancer
D Shiokawa, H Sakai, H Ohata, T Miyazaki, Y Kanda… - Cancer research, 2020 - AACR
Cancer chemoresistance is often attributed to the presence of cancer stem cell (CSC)-like
cells, but whether they are homogeneously chemoresistant remains unclear. We previously …
cells, but whether they are homogeneously chemoresistant remains unclear. We previously …
Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma
JT Topham, ES Tsang, JM Karasinska… - Nature …, 2022 - nature.com
Oncogenic KRAS mutations are absent in approximately 10% of patients with metastatic
pancreatic ductal adenocarcinoma (mPDAC) and may represent a subgroup of mPDAC with …
pancreatic ductal adenocarcinoma (mPDAC) and may represent a subgroup of mPDAC with …
[HTML][HTML] Mitotic implantation of the transcription factor prospero via phase separation drives terminal neuronal differentiation
Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier
to cellular reprogramming. It remains obscure how heterochromatin remodeling is …
to cellular reprogramming. It remains obscure how heterochromatin remodeling is …
Hold on or cut? Integrin-and MMP-mediated cell–matrix interactions in the tumor microenvironment
S Niland, JA Eble - International journal of molecular sciences, 2020 - mdpi.com
The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis
Y Wang, M Luo, F Wang, Y Tong, L Li, Y Shu… - Nature …, 2022 - nature.com
Tumour cell metabolic plasticity is essential for tumour progression and therapeutic
responses, yet the underlying mechanisms remain poorly understood. Here, we identify …
responses, yet the underlying mechanisms remain poorly understood. Here, we identify …
Genome-wide association study to identify susceptibility loci that modify radiation-related risk for breast cancer after childhood cancer
LM Morton, JN Sampson, GT Armstrong… - JNCI: Journal of the …, 2017 - academic.oup.com
Background Childhood cancer survivors treated with chest-directed radiotherapy have
substantially elevated risk for developing breast cancer. Although genetic susceptibility to …
substantially elevated risk for developing breast cancer. Although genetic susceptibility to …
MMP14 in sarcoma: a regulator of tumor microenvironment communication in connective tissues
Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …