Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease. Most studies have
focused on short‐term prognosis, whereas factors associated with long‐term survival are …

Cancer chemoresistance is often attributed to the presence of cancer stem cell (CSC)-like
cells, but whether they are homogeneously chemoresistant remains unclear. We previously …

Oncogenic KRAS mutations are absent in approximately 10% of patients with metastatic
pancreatic ductal adenocarcinoma (mPDAC) and may represent a subgroup of mPDAC with …

Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier
to cellular reprogramming. It remains obscure how heterochromatin remodeling is …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

Tumour cell metabolic plasticity is essential for tumour progression and therapeutic
responses, yet the underlying mechanisms remain poorly understood. Here, we identify …

Background Childhood cancer survivors treated with chest-directed radiotherapy have
substantially elevated risk for developing breast cancer. Although genetic susceptibility to …

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …