Depression is an effect of complex interactions between genetic, epigenetic and
environmental factors. It is well established that stress responses are associated with …

Genome-wide association studies (GWASs) have identified numerous risk genes for
depression. Nevertheless, genes crucial for understanding the molecular mechanisms of …

Major depressive disorder (MDD) is frequently characterized as a disorder of the
disconnection syndrome. Diffusion tensor imaging (DTI) has played a critical role in …

Background Disorders of mood and cognition are prevalent, disabling, and notoriously
difficult to treat. Fueling this challenge in treatment is a significant gap in our understanding …

Background Early‐onset (EO) major depressive disorder (MDD) patients experience more
depressive episodes and an increased risk of relapse. Thus, on a neurobiological level …

Background Major depressive disorder (MDD) is characterized by impairments in emotional
and cognitive functions. Emerging studies have shown that cognition and emotion interact …

Animal models of stress and related conditions, including depression, have shown that
elevated peripheral levels of inflammatory cytokines have downstream consequences on …

Abstract Background Major Depressive Disorder (MDD) is characterized by aberrant resting-
state functional connectivity (FC) in anterior cingulate regions (eg, subgenual anterior …

Dysfunctional activity of the rostral anterior cingulate cortex (rACC)–an extensively
connected hub region of the default mode network–has been broadly linked to cognitive and …

Background There have been significant challenges in understanding functional brain
connectivity associated with adolescent depression, including the need for a more …