Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …

One of the most frequent complications in patients with diabetes mellitus is diabetic
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …

Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy,
which is the largest single cause of end‐stage renal disease and a medical catastrophe of …

Objective To examine the effects of reduction in dietary sodium intake on cardiovascular
events using data from two completed randomised trials, TOHP I and TOHP II. Design Long …

Blood pressure (BP)-related diseases, specifically, stroke, coronary heart disease, heart
failure, and kidney disease, are leading causes of morbidity and mortality in the United …

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of
glomerular injury? Although the glomerulus, particularly the mesangium, has been the focus …

Tumor necrosis factor (TNF), initially reported to induce tumor cell apoptosis and cachexia, is
now considered a central mediator of a broad range of biological activities from cell …

The formation of advanced glycation end products (AGEs) on extracellular matrix
components leads to accelerated increases in collagen cross linking that contributes to …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and a main
contributing factor for cardiovascular morbidity and mortality in patients with diabetes …

The vascular hallmark of subjects with end-stage renal disease undergoing hemodialysis is
increased aortic stiffness, a phenomenon independent of mean arterial blood pressure, wall …