The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …

Abnormal placentation has been noticed in a variety of pregnancy complications such as
miscarriage, early-onset preeclampsia, and fetal growth restriction. Defects in the …

Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave
survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells …

We present a unifying theory to explain cancer recurrence, therapeutic resistance, and
lethality. The basis of this theory is the formation of simultaneously polyploid and aneuploid …

Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

Human pregnancy depends on the proper development of the embryo prior to implantation
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …

Progress in the understanding of the biology of perinatal tissues has contributed to the
breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth …