BACKGROUND: The widely expressed Dps proteins, so named after the DNA-binding
properties of the first characterized member of the family in Escherichia coli, are considered …

This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …

Loading of the replicative DNA helicase at origins of replication is of central importance in
DNA replication. As the first of the replication fork proteins assemble at chromosomal origins …

The DNA-binding protein from starved cells, Dps, is a universally conserved prokaryotic
ferritin that, in many species, also binds DNA. Dps homologs have been identified in the vast …

Dps-like proteins are key factors involved in the protection of prokaryotic cells from oxidative
damage. They act by either oxidizing iron to prevent the formation of oxidative radicals or by …

Replication of the bacterial chromosome initiates at a single origin of replication that is
called oriC. This occurs via the concerted action of numerous proteins, including DnaA …

New antibiotics with novel modes of action are required to combat the growing threat posed
by multi-drug resistant bacteria. Over the last decade, genome sequencing and other high …

The stringent response enables bacteria to respond to a variety of environmental stresses,
especially various forms of nutrient limitation. During the stringent response, the cell …

During the cell division cycle of all bacteria, DNA-protein complexes termed orisomes trigger
the onset of chromosome duplication. Orisome assembly is both staged and stringently …

To initiate DNA replication, DnaA recognizes and binds to specific sequences within the
Escherichia coli chromosomal origin (oriC), and then unwinds a region within oriC. Next …