While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

The i-motif represents a paradigmatic example of the wide structural versatility of nucleic
acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held …

DNA i-motifs (iMs) are non-canonical C-rich secondary structures implicated in numerous
cellular processes. Though iMs exist throughout the genome, our understanding of iM …

Conspectus This Account highlights the structural features that render 2′-deoxy-2′-fluoro-
arabinonucleic acid (FANA) an ideal tool for mimicking DNA secondary structures and …

DNA sequences rich in cytosine have the propensity, under acidic pH, to fold into four‐
stranded intercalated DNA structures called i‐motifs. Recent studies have provided …

Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro at
acidic pH. While studies have suggested that i-motifs may form in cells, little is known about …

We report here the solution structure of several repetitive DNA sequences containing d
(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif …

Owing to the unique physical properties of a fluorine atom, incorporating fluoro-modifications
into nucleic acids offers striking biophysical and biochemical features, and thus significantly …

DNA-intercalated motifs (iMs) are facile scaffolds for the design of various pH-responsive
nanomachines, including biocompatible pH sensors. First, DNA pH sensors relied on …

DNA is naturally dynamic and can self-assemble into alternative secondary structures
including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich …