Vitamin D shows a variety of pleiotropic activities which cannot be fully explained by the
stimulation of classic pathway-and vitamin D receptor (VDR)-dependent transcriptional …

Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated
destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence …

The genomic actions of the vitamin D are mediated via its biologically most potent metabolite
1α, 25‐dihydroxyvitamin D3 (1, 25 (OH) 2D3) and the transcription factor vitamin D receptor …

The biological functions of 1α, 25-dihydroxyvitamin D3 are regulated by nuclear receptor
vitamin D receptor (VDR). The expression level of VDR is high in intestine. VDR is an …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease, due to a large number of islet β
cells damaged, resulting in an absolute lack of insulin, ultimately relying on insulin therapy …

The effects of vitamin D on the immune function have been recognized for more than a
quarter of a century. However, our understanding of the multifactorial nature of the effects of …

Nuclear receptors (NRs) have historically been at the forefront of cancer research, where
they are known to act as critical regulators of disease. They also serve as biomarkers for …

Epidemiological studies have identified vitamin D (25 (OH) D) deficiency to be highly
prevalent among patients with inflammatory bowel disease (IBD), and low serum levels …

Vitamin D has a plethora of functions that are important for the maintenance of general
health and in particular, the functional integrity of the immune system, such as promoting an …

The germinal center (GC) response is critical for both effective adaptive immunity and
establishing peripheral tolerance by limiting autoreactive B cells. Dysfunction in these …