p38 MAPK signaling in osteoblast differentiation

E Rodríguez-Carballo, B Gámez… - Frontiers in cell and …, 2016 - frontiersin.org
The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …

Cellular signalling and photobiomodulation in chronic wound repair

TS Leyane, SW Jere, NN Houreld - International Journal of Molecular …, 2021 - mdpi.com
Photobiomodulation (PBM) imparts therapeutically significant benefits in the healing of
chronic wounds. Chronic wounds develop when the stages of wound healing fail to progress …

Human mesenchymal stem cell derived exosomes enhance cell‐free bone regeneration by altering their miRNAs profiles

M Zhai, Y Zhu, M Yang, C Mao - Advanced Science, 2020 - Wiley Online Library
Implantation of stem cells for tissue regeneration faces significant challenges such as
immune rejection and teratoma formation. Cell‐free tissue regeneration thus has a potential …

[HTML][HTML] Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities

Y Liu, C Wang, G Wang, Y Sun, Z Deng, L Chen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Osteoporosis is a severe bone disorder that is a threat to our aging population.
Excessive osteoclast formation and bone resorption lead to changes in trabecular bone …

[HTML][HTML] Irisin as an agent for protecting against osteoporosis: A review of the current mechanisms and pathways

X Hu, Z Wang, W Wang, P Cui, C Kong, X Chen… - Journal of Advanced …, 2024 - Elsevier
Background Osteoporosis is recognized as a skeletal disorder characterized by diminished
bone tissue quality and density. Regular physical exercise is widely acknowledged to …

[HTML][HTML] Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice

Z Ou, J Zhao, L Zhu, L Huang, Y Ma, C Ma… - Biomedicine & …, 2019 - Elsevier
Abstract λ-Carrageenan (Carr), a seaweed polysaccharide, is used as a proinflammatory
agent in research. Betulinic acid (BA), a naturally occurring pentacyclic triterpenoid, exerts …

Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation

X Gu, M Li, Y Jin, D Liu, F Wei - BMC genetics, 2017 - Springer
Background Researchers have been exploring the molecular mechanisms underlying the
control of periodontal ligament stem cell (PDLSC) osteogenic differentiation. Recently, long …

[HTML][HTML] Magnesium-containing bioceramics stimulate exosomal miR-196a-5p secretion to promote senescent osteogenesis through targeting Hoxa7/MAPK signaling …

L Qi, X Fang, J Yan, C Pan, W Ge, J Wang, SGF Shen… - Bioactive Materials, 2024 - Elsevier
Stem cell senescence is characterized by progressive functional dysfunction and secretory
phenotypic changes including decreased proliferation, dysfunction of osteogenic and …

[HTML][HTML] Long-term BPA exposure leads to bone malformation and abnormal expression of MAPK/Wnt/FoxO signaling pathway genes in zebrafish offspring

Z Zhu, J Wang, Q Cao, S Liu, W Wei, H Yang… - Ecotoxicology and …, 2022 - Elsevier
Bisphenol A (BPA) is one of the world's most widely used plasticizer, and its hazardous
impacts have been well studied. However, few studies focused on the effects of parental …

A novel RANKL‐targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species

G Hong, Z Chen, X Han, L Zhou, F Pang… - Clinical and …, 2021 - Wiley Online Library
Background and purpose Osteoporosis is characterized by excessive bone resorption due
to enhanced osteoclast activation. Stimulation of nuclear factor of activated T cells 1 …