Fetal surgery is an established but still rapidly evolving specialty, born from the rationale that
destructive embryologic processes, recognized early in gestation, can be curtailed by …

Nanoparticle-based drug delivery systems have the potential to revolutionize medicine, but
their low vascular permeability and rapid clearance by phagocytic cells have limited their …

Prenatal stem cell‐based regenerative therapies have progressed substantially and have
been demonstrated as effective treatment options for fetal diseases that were previously …

Advanced therapy medicinal products (ATMPs) are medicines for human use based on
genes, cells or tissue engineering. After clear successes in adults, the nascent technology …

Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-
million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII …

Hemophilia A (HA) is a bleeding disorder characterized by spontaneous and prolonged
hemorrhage. The disease is caused by mutations in the coagulation factor 8 gene (F8) …

Abstract Background Hemophilia A (HA) is an X-linked recessive disorder caused by
mutations in the Factor VIII (FVIII) gene leading to deficient blood coagulation. As a …

BACKGROUND Endothelial colony-forming cells (ECFCs) have been implicated in the
process of vascularization, which includes vasculogenesis and angiogenesis …

Endothelial cell (EC) transplantation via injectable collagen hydrogel has received much
attention as a potential treatment for various vascular diseases. However, the therapeutic …

Background Biliary atresia (BA) is an intractable disease of unknown cause that develops in
the neonatal period. It causes jaundice and liver damage due to the destruction of …