Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM)
in 1998. There is significant variation in the dietary requirement for choline that can be …

Choline is an essential nutrient, but is also formed by de novo synthesis. Choline and its
derivatives serve as components of structural lipoproteins, blood and membrane lipids, and …

▪ Abstract Choline is an essential nutrient needed for the structural integrity and signaling
functions of cell membranes; for normal cholinergic neurotransmission; for normal muscle …

The foundations of neurodevelopment across an individual's lifespan are established in the
first 1000 days of life (2 years). During this period an adequate supply of nutrients are …

Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here,
we assessed the impact of gut microbial choline metabolism on bacterial fitness and host …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Background The importance of maternal dietary choline for fetal neural development and
later cognitive function has been well-documented in experimental studies. Although choline …

Evidence is growing for the long-term effects of environmental factors during early-life on
later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene …

Choline, a micronutrient found in food, serves as the starting material for several important
metabolites that play key roles in fetal development, particularly the brain. Although human …

Choline is derived not only from the diet, but also from de novo synthesis. It is important for
methyl-group metabolism, the formation of membranes, kidney function, and …