Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning
G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …
The coxibs, selective inhibitors of cyclooxygenase-2
GA FitzGerald, C Patrono - New England Journal of Medicine, 2001 - Mass Medical Soc
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual
pain, and headache. Although they are effective, their long-term use is limited by …
pain, and headache. Although they are effective, their long-term use is limited by …
[HTML][HTML] Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase
(COX)-2 enabling the biosynthesis of R-containing precursors of endogenous …
(COX)-2 enabling the biosynthesis of R-containing precursors of endogenous …
Lipid mediator class switching during acute inflammation: signals in resolution
Abstract Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas
lipoxins (LXs) have unique anti-inflammatory actions. Temporal analyses of these …
lipoxins (LXs) have unique anti-inflammatory actions. Temporal analyses of these …
[HTML][HTML] Cardiovascular risk of nonsteroidal anti-inflammatory drugs: an under-recognized public health issue
Z Varga, S rafay ali Sabzwari, V Vargova - Cureus, 2017 - ncbi.nlm.nih.gov
Nonsteroidal anti-inflammatory drugs (NSAIDs) are drugs with analgesic, anti-inflammatory,
and antipyretic activity. Their effect is achieved by the reduction in synthesis of prostanoids …
and antipyretic activity. Their effect is achieved by the reduction in synthesis of prostanoids …
Risk of cardiovascular events associated with selective COX-2 inhibitors
Atherosclerosis is a process with inflammatory features and selective cyclooxygenase 2
(COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting …
(COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting …
Preconditioning the myocardium: from cellular physiology to clinical cardiology
Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …
The late phase of preconditioning
R Bolli - Circulation research, 2000 - Am Heart Assoc
Unlike the early phase of preconditioning (PC), which lasts 2 to 3 hours and protects against
infarction but not against stunning, the late phase of PC lasts 3 to 4 days and protects …
infarction but not against stunning, the late phase of PC lasts 3 to 4 days and protects …
COX-2 and beyond: approaches to prostaglandin inhibition in human disease
GA FitzGerald - Nature Reviews Drug Discovery, 2003 - nature.com
Selective inhibitors of cyclooxygenase (COX)-2 afford relief from pain and inflammation.
They could also prove useful in the chemoprevention of cancer and are being investigated …
They could also prove useful in the chemoprevention of cancer and are being investigated …
Pro-resolving mediators in the regulation of periodontal disease
TE Van Dyke - Molecular aspects of medicine, 2017 - Elsevier
Periodontitis is an inflammatory disease of the supporting structures of the dentition that is
initiated by bacteria that form a biofilm on the surface of the teeth. The pathogenesis of the …
initiated by bacteria that form a biofilm on the surface of the teeth. The pathogenesis of the …