The kallikrein-kinin system: current and future pharmacological targets

ME Moreau, N Garbacki, G Molinaro… - Journal of …, 2005 - jstage.jst.go.jp
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results
in the release of vasoactive kinins (bradykinin-related peptides). This complex system …

Identification and molecular interactions of novel ACE inhibitory peptides from rapeseed protein

X Duan, Y Dong, M Zhang, Z Li, G Bu, F Chen - Food Chemistry, 2023 - Elsevier
Plant-derived bioactive peptides have drawn much attention because of their physiological
functions. This study aimed to evaluate bioactive peptides in rapeseed protein and identify …

Survey of the year 2004: literature on applications of isothermal titration calorimetry

A Ababou, JE Ladbury - Journal of Molecular Recognition: An …, 2006 - Wiley Online Library
The market for commercially available isothermal titration calorimeters continues to grow as
new applications and methodologies are developed. Concomitantly the number of users …

Antihypertensive effect of quinoa protein under simulated gastrointestinal digestion and peptide characterization

H Guo, Y Hao, A Richel, N Everaert… - Journal of the …, 2020 - Wiley Online Library
BACKGROUND Quinoa protein is a potential source of bioactive peptides. Although some
studies have demonstrated its angiotensin converting enzyme (ACE) inhibitory properties …

Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design

HR Corradi, SLU Schwager, AT Nchinda… - Journal of molecular …, 2006 - Elsevier
Human somatic angiotensin I-converting enzyme (sACE) is a key regulator of blood
pressure and an important drug target for combating cardiovascular and renal disease …

Antihypertensive effects, molecular docking study, and isothermal titration calorimetry assay of angiotensin I-converting enzyme inhibitory peptides from Chlorella …

J Xie, X Chen, J Wu, Y Zhang, Y Zhou… - Journal of Agricultural …, 2018 - ACS Publications
The aim of this work is to explore angiotensin I-converting enzyme (ACE) inhibitory peptides
from Chlorella vulgaris (C. vulgaris) and discover the inhibitory mechanism of the peptides …

Studies on the molecular recognition between bioactive peptides and angiotensin‐converting enzyme

AS Pina, ACA Roque - Journal of Molecular Recognition: An …, 2009 - Wiley Online Library
High blood pressure or hypertension is a condition affecting many individuals and
represents a controllable risk factor for cardiovascular diseases such as coronary heart …

Screening potential hypertensive peptides using two consecutive bioassay-guided SPE fractionations and identification of an ACE inhibitory peptide, DHSTAVW (DW7 …

CCY Sutopo, N Aznam, R Arianingrum, JL Hsu - Peptides, 2023 - Elsevier
The pearl garlic (Allium sativum L.) protein (PGP) was digested using pepsin, trypsin, α-
chymotrypsin, thermolysin, and simulated gastrointestinal digestion. The α-chymotrypsin …

Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics

GE Cozier, L Lubbe, ED Sturrock… - The FEBS …, 2021 - Wiley Online Library
Angiotensin‐1‐converting enzyme (ACE) is a key enzyme in the renin–angiotensin–
aldosterone and kinin systems where it cleaves angiotensin I and bradykinin peptides …

Acidity, lipophilicity, solubility, absorption, and polar surface area of some ACE inhibitors

M Remko - Chemical Papers, 2007 - Springer
Computational chemical methods have been used to correlate the molecular properties of
the 10 ACE inhibitors (captopril, enalapril, perindopril, lisinopril, ramipril, trandolapril …