Metabolic and haemodynamic perturbations and their interaction drive the development of
diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD) …

Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in
the development of diabetic microangiopathy in the initial stage of diabetic diseases …

Synthesis and deposition of extracellular matrix (ECM) within the glomerulus and interstitium
characterizes renal fibrosis, but the mechanisms underlying this process are incompletely …

Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the
pathogenesis of microvascular complications of diabetes, including diabetic nephropathy …

Endothelial hyperpermeability is a significant problem in vascular inflammation associated
with trauma, ischaemia–reperfusion injury, sepsis, adult respiratory distress syndrome …

Diabetic Nephropathy (DN) is believed to be a major microvascular complication of
diabetes. The hallmark of DN includes deposition of Extracellular Matrix (ECM) proteins …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Diabetes is increasing in prevalence and is the leading cause of end-stage renal disease in
the United States. Diabetic kidney disease is considered a proteinuric glomerular disease …

Although several recent publications have suggested that microRNAs contribute to the
pathogenesis of diabetic nephropathy, the role of miRNAs in vivo still remains poorly …

RhoA/Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) has
appeared as a potential therapeutic target in numerous diseases, because of its preventing …