[HTML][HTML] Mechanisms and metabolic implications of regional differences among fat depots
T Tchkonia, T Thomou, YI Zhu, I Karagiannides… - Cell metabolism, 2013 - cell.com
Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex,
genetic background, disease state, certain drugs and hormones, development, and aging …
genetic background, disease state, certain drugs and hormones, development, and aging …
Human haematopoietic stem cell development: from the embryo to the dish
Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …
haematopoietic system. Understanding how early haematopoietic development occurs is of …
Haematopoietic stem and progenitor cells from human pluripotent stem cells
A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …
embryonic development through stepwise exposure to morphogens, or by conversion of one …
DNA-dependent formation of transcription factor pairs alters their binding specificity
Gene expression is regulated by transcription factors (TFs), proteins that recognize short
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …
Developmental gene networks: a triathlon on the course to T cell identity
MA Yui, EV Rothenberg - Nature Reviews Immunology, 2014 - nature.com
Cells acquire their ultimate identities by activating combinations of transcription factors that
initiate and sustain expression of the appropriate cell type-specific genes. T cell …
initiate and sustain expression of the appropriate cell type-specific genes. T cell …
The role of HOX genes in normal hematopoiesis and acute leukemia
RA Alharbi, R Pettengell, HS Pandha, R Morgan - Leukemia, 2013 - nature.com
The homeobox (HOX) genes are a highly conserved family of homeodomain-containing
transcription factors that specify cell identity in early development and, subsequently, in a …
transcription factors that specify cell identity in early development and, subsequently, in a …
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors
Human pluripotent stem cells (hPSCs) represent a promising source of patient-specific cells
for disease modeling, drug screens, and cellular therapies. However, the inability to derive …
for disease modeling, drug screens, and cellular therapies. However, the inability to derive …
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
MM Dzama, M Steiner, J Rausch… - Blood, The Journal …, 2020 - ashpublications.org
The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a
potential opportunity for treatment of NPM1-mutant (NPM1 mut) and MLL-rearranged (MLL-r) …
potential opportunity for treatment of NPM1-mutant (NPM1 mut) and MLL-rearranged (MLL-r) …
TET1 plays an essential oncogenic role in MLL-rearranged leukemia
The ten-eleven translocation 1 (TET1) gene is the founding member of the TET family of
enzymes (TET1/2/3) that convert 5-methylcytosine to 5-hydroxymethylcytosine. Although …
enzymes (TET1/2/3) that convert 5-methylcytosine to 5-hydroxymethylcytosine. Although …
Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets
CT Collins, JL Hess - Oncogene, 2016 - nature.com
HOXA9 is a homeodomain-containing transcription factor that has an important role in
hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A …
hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A …