Synergy between amyloid-β and tau in Alzheimer's disease
Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …
Protein transmission in neurodegenerative disease
Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
[HTML][HTML] Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target …
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease
N Mattsson-Carlgren, E Andersson, S Janelidze… - Science …, 2020 - science.org
The links between β-amyloid (Aβ) and tau in Alzheimer's disease are unclear. Cognitively
unimpaired persons with signs of Aβ pathology had increased cerebrospinal fluid (CSF) …
unimpaired persons with signs of Aβ pathology had increased cerebrospinal fluid (CSF) …
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
M Jucker, LC Walker - Nature neuroscience, 2018 - nature.com
Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …
[HTML][HTML] Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
IC Stancu, N Cremers, H Vanrusselt, J Couturier… - Acta …, 2019 - Springer
Brains of Alzheimer's disease patients are characterized by the presence of amyloid plaques
and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial role …
and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial role …
[HTML][HTML] MAPT mutations, tauopathy, and mechanisms of neurodegeneration
In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …
[HTML][HTML] Mechanisms of pathogenic tau and Aβ protein spreading in Alzheimer's disease
P d 'Errico, M Meyer-Luehmann - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is pathologically defined by extracellular accumulation of amyloid-
β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of …
β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of …
Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease
Alzheimer's disease is characterized by the histopathological presence of amyloid-β
plaques and tau-containing neurofibrillary tangles. Microglial activation is also a recognized …
plaques and tau-containing neurofibrillary tangles. Microglial activation is also a recognized …
[HTML][HTML] What is the evidence that tau pathology spreads through prion-like propagation?
Emerging experimental evidence suggests that the spread of tau pathology in the brain in
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …