Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

Bioprinting is a method by which a cell-encapsulating bioink is patterned to create complex
tissue architectures. Given the potential impact of this technology on neural research, we …

Protein misfolding and aggregation is a common hallmark in neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and fronto-temporal dementia …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide, being characterized by the progressive loss of dopaminergic neurons in the …

Neurons affected in a wide variety of unrelated adult-onset neurodegenerative diseases
(AONDs) typically exhibit a “dying back” pattern of degeneration, which is characterized by …

Neuroinflammation is an important factor contributing to cognitive impairment and
neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Huntington's disease (HD) is a neurodegenerative disease characterized by prominent loss
of neurons in the striatum and cortex. Traditionally research in HD has focused on brain …

Animal models are extremely valuable to help us understand the pathogenesis of
neurodegenerative disorders and to find treatments for them. Since large animals are more …

Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively
worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in …