Oxidative Stress‐Mediated Blood‐Brain Barrier (BBB) Disruption in Neurological Diseases

K Song, Y Li, H Zhang, N An, Y Wei… - Oxidative medicine …, 2020 - Wiley Online Library
The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Adipokines, diabetes and atherosclerosis: an inflammatory association

LC Freitas Lima, VA Braga… - Frontiers in …, 2015 - frontiersin.org
Cardiovascular diseases can be considered the most important cause of death in diabetic
population and diabetes can in turn increase the risk of cardiovascular events. Inflammation …

Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation

DJ Conklin, S Schick, MJ Blaha… - American Journal …, 2019 - journals.physiology.org
Although substantial evidence shows that smoking is positively and robustly associated with
cardiovascular disease (CVD), the CVD risk associated with the use of new and emerging …

The role of the blood–brain barrier in hypertension

A Setiadi, WS Korim, K Elsaafien… - Experimental …, 2018 - Wiley Online Library
New Findings What is the topic of this review? This review highlights the importance of the
blood–brain barrier in the context of diseases involving autonomic dysfunction, such as …

Compromised blood–brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension

VC Biancardi, JE Stern - The Journal of physiology, 2016 - Wiley Online Library
Angiotensin II (AngII) is a pivotal peptide implicated in the regulation of blood pressure. In
addition to its systemic vascular and renal effects, AngII acts centrally to modulate the …

Neuroinflammation in heart failure: new insights for an old disease

HS Díaz, C Toledo, DC Andrade… - The Journal of …, 2020 - Wiley Online Library
Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people
worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease …

Targeting the renin-angiotensin system (RAS) for neuropsychiatric disorders

AS de Miranda, DS Macedo, NP Rocha… - Current …, 2024 - benthamdirect.com
Background: Neuropsychiatric disorders, such as mood disorders, schizophrenia, and
Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and …

Neurogenic hypertension, the blood–brain barrier, and the potential role of targeted nanotherapeutics

RNL Lamptey, C Sun, B Layek, J Singh - International Journal of …, 2023 - mdpi.com
Hypertension is a major health concern globally. Elevated blood pressure, initiated and
maintained by the brain, is defined as neurogenic hypertension (NH), which accounts for …

Acute treatment with lauric acid reduces blood pressure and oxidative stress in spontaneously hypertensive rats

NFB Alves, TM de Queiroz… - Basic & clinical …, 2017 - Wiley Online Library
The effects of acute administration of lauric acid (LA), the most abundant medium‐chain fatty
acid of coconut oil, on blood pressure, heart rate and oxidative stress were investigated in …

Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II–induced hypothalamic reactive oxygen species and hypertension

HW Wang, BS Huang, RA White, A Chen, M Ahmad… - Neuroscience, 2016 - Elsevier
Activation of angiotensinergic pathways by central aldosterone (Aldo)-mineralocorticoid
receptor (MR) pathway plays a critical role in angiotensin II (Ang II)-induced hypertension …